Challenges associated with hereditary cancer susceptibility testing.
نویسنده
چکیده
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منابع مشابه
Individual and family characteristics associated with BRCA1/2 genetic testing in high-risk families.
BACKGROUND Little is known about family members' interrelated decisions to seek genetic testing for breast cancer susceptibility. METHODS The specific aims of this cross-sectional, descriptive, cohort study were (i) to examine whether individual and family characteristics have a direct effect on women's decisions to use genetic testing for hereditary susceptibility to breast cancer and (ii) t...
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Digital Object Identifier: 10.1188/03.CJON.591-594 In 1994, the first cancer susceptibility gene to be associated with hereditary breast and ovarian cancer was identified and became known as breast cancer gene 1 (BRCA1). In 1995, a second gene was identified and became known as BRCA2 (Calus, Schildkraut, Thompson, & Risch, 1996). With the identification of these two genes, a new field emerged i...
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Genetic factors are likely to be the primary determinants in around 5–10% of cancer patients. Over the last decade the identification of some of these cancer susceptibility genes has revolutionised our understanding of cancer in general. In addition, it has allowed us to improve our management of patients in those families with a genetic predisposition by offering presymptomatic testing and hen...
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Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant cancer susceptibility syndrome associated with inherited defects in the DNA mismatch repair system. HNPCC family members are at high risk for developing colorectal, endometrial, and ovarian cancers. Studies of HNPCC families have helped define the important role that mismatch repair genes play in the molecular pathogenes...
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ورودعنوان ژورنال:
- Clinical journal of oncology nursing
دوره 18 1 شماره
صفحات -
تاریخ انتشار 2014